Uruguay and Portugal will face each other in what is expected to be a highly-contested match on Saturday. But now that they're here, the knockouts begin and the room for error gets even smaller.
Hours after Messi's World Cup came to an end with a 4-3 defeat to France, Ronaldo and Portugal fell 2-1 to Uruguay, meaning the Real Madrid star will not be able to add to his impressive trophy case in Russian Federation.
The World Cup match between Uruguay and Portugal will be broadcast live on Fox. Joao Moutinho, benched against Iran, will likely come back into the first XI.
Against Uruguay, though, we saw the reality of Portugal's overreliance on the Real Madrid forward.
All five of Uruguay'sgoals at the 2018 World Cup have been scored from set-pieces (3 from corners, 1 from direct free-kick and 1 from indirect free-kick).
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Fernando Santos threw on Andre Silva as Portugal tried to find a way through, but defensive duo Diego Godin and Jose Gimenez held a frustrated Ronaldo at bay, the Portugal captain picking up a late booking for dissent as his emotions ran overboard in the closing stages. They owe much to Cristiano Ronaldo who is in good form and they may look to him to give them their moments of star quality. Meanwhile, three of Portugal's last four goals have come from outside the box.
If Uruguayan defenders manage to get the best of Cristiano Ronaldo and get him sent off early in the game, it might be effectively game over for Portugal in Russian Federation.
Uruguay's previous five goals at Russian Federation 2018 all came from set-pieces but they opened the scoring in the seventh minute with a goal of the highest quality. "I believe that our players are prepared". "We're there to win".
Away from the first game against Spain, Portugal haven't been great.
But BBC commentator Dion Dublin thinks they need something more if they are to mount a comeback.
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